A fermented mixed tea made with camellia (Camellia japonica) and third-crop green tea leaves prevents nonalcoholic steatohepatitis in Sprague-Dawley rats fed a high-fat and high-cholesterol diet.
Hepatobiliary Surg Nutr
; 7(3): 175-184, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-30046568
ABSTRACT
BACKGROUND:
Established treatments for non-alcoholic steatohepatitis (NASH) are few, thus it is imperative to develop novel dietary strategies that can prevent NASH. A fermented mixed tea (FMT) made with Camellia japonica (Japanese camellia) and third- crop green tea leaves by tea-rolling processing was reported to reduce body weight and adipose tissue weight in Sprague-Dawley (SD) rats. Because visceral fat is one of the most important factors for the development of hepatic steatosis, this FMT supplementation can be a candidate dietary strategy for the prevention of NASH.METHODS:
Nine-week-old male SD rats were fed a high-fat and high-cholesterol (HFC) diets with or without FMT (camellia and third-crop green tea leaves at ratios of 15, 12 and 11) for 9 weeks (n=6-7/group). Histopathology, serology and expressions of fibrogenetic, proinflammatory, oxidative stress and lipid metabolism-related genes in the liver were evaluated.RESULTS:
Histologically, HFC diet with FMT at a ratio of 15 dramatically reduced NASH progression (14%) compared to the HFC diet without FMT (100%). FMT at a ratio of 15 reduced hepatic steatosis due to the activation of microsomal triglyceride transfer protein, and FMT at a ratio of 12 reduced mRNA levels of some proinflammatory, lipid metabolism-related, fibrogenic and oxidative stress marker genes.CONCLUSIONS:
Our data suggest that FMT at a ratio of 15 or 12 likely possesses a preventive effect on NASH progression.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article