In vivo biodistribution and toxicology studies of cadmium-free indium-based quantum dot nanoparticles in a rat model.
Nanomedicine
; 14(8): 2644-2655, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30048815
ABSTRACT
Quantum dot (QD) nanoparticles are highly promising contrast agents and probes for biomedical applications owing to their excellent photophysical properties. However, toxicity concerns about commonly used cadmium-based QDs hinder their translation to clinical applications. In this study we describe the in vivo biodistribution and toxicology of indium-based water soluble QDs in rats following intravenous administration. The biodistribution measured at up to 90â¯days showed that QDs mainly accumulated in the liver and spleen, with similar elimination kinetics to subcutaneous administration. Evidence for QD degradation in the liver was found by comparing photoluminescence measurements versus elemental analysis. No organ damage or histopathological lesions were observed for the QDs treated rats after 24â¯h, 1 and 4â¯weeks following intravenous administration at 12.5â¯mg/kg or 50â¯mg/kg. Analysis of serum biochemistry and complete blood counts found no toxicity. This work supports the strong potential of indium-based QDs for translation into the clinic.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cádmio
/
Pontos Quânticos
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Nanopartículas
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Índio
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Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article