Long-term Response to First-line Pazopanib Therapy in mRCC Patients: A Multicenter Italian Experience.
Anticancer Res
; 38(8): 4913-4918, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-30061269
ABSTRACT
BACKGROUND/AIM:
The specific characteristics of patients who are most likely to benefit from pazopanib therapy are still uncertain. We report on the results of an Italian multicenter, retrospective analysis investigating the factors associated with longer response to first-line pazopanib in patients with metastatic renal cell carcinoma. PATIENTS ANDMETHODS:
Adult patients were considered if they had received treatment with pazopanib (800 mg/day) for >12 months in the first-line setting.RESULTS:
In total, 112 patients were evaluated. Median duration of pazopanib treatment was 22.6 months (IQR 17.8 months). Median PFS was 22.6 months (95%CI= 20.2-25.0). Eighty-three patients (74.1%) had a PFS ≥18 months. Median OS was 32.9 months (95%CI=30.2-35.6). At statistical analysis, only PS score (1+ vs. 0) was significantly associated with PFS (HR=1.76; 95%CI=1.02-3.05; p=0.04).CONCLUSION:
Pazopanib therapy may be suitable for all patients with mRCC, and especially in those with PS 0.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
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Sulfonamidas
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Carcinoma de Células Renais
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Inibidores da Angiogênese
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Receptores de Fatores de Crescimento do Endotélio Vascular
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Neoplasias Renais
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article