Application of nSMOL coupled with LC-MS bioanalysis for monitoring the Fc-fusion biopharmaceuticals Etanercept and Abatacept in human serum.

Iwamoto, Noriko; Yokoyama, Kotoko; Takanashi, Megumi; Yonezawa, Atsushi; Matsubara, Kazuo; Shimada, Takashi

Iwamoto, Noriko; Yokoyama, Kotoko; Takanashi, Megumi; Yonezawa, Atsushi; Matsubara, Kazuo; Shimada, Takashi.

Afiliação

Iwamoto N; Leading Technology of Bioanalysis and Protein Chemistry SHIMADZU Corporation Kyoto Japan.
Yokoyama K; Leading Technology of Bioanalysis and Protein Chemistry SHIMADZU Corporation Kyoto Japan.
Takanashi M; Leading Technology of Bioanalysis and Protein Chemistry SHIMADZU Corporation Kyoto Japan.
Yonezawa A; Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan.
Matsubara K; Graduate School of Pharmaceutical Sciences Kyoto University Kyoto Japan.
Shimada T; Department of Clinical Pharmacology and Therapeutics Kyoto University Hospital Kyoto Japan.

Pharmacol Res Perspect ; 6(4): e00422, 2018 07.

Article em En | MEDLINE | ID: mdl-30062014

Assuntos

Abatacepte/sangue; Anti-Inflamatórios/sangue; Etanercepte/sangue; Imunossupressores/sangue; Soro/química; Cromatografia Líquida; Humanos; Proteólise; Espectrometria de Massas em Tandem

Palavras-chave

Abatacept; Etanercept; LCMS; bioanalysis; clinical pharmacokinetics; nanosurface and molecularorientation limited proteolysis; therapeutic drug monitoring

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Soro / Abatacepte / Etanercepte / Imunossupressores / Anti-Inflamatórios Tipo de estudo: Guideline Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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