Healthy Adult LDL-C Bears Reverse Association with Serum IL-17A Levels.
Curr Chem Genom Transl Med
; 12: 1-8, 2018.
Article
em En
| MEDLINE
| ID: mdl-30069429
ABSTRACT
BACKGROUND:
Hypercholesterolemia is a modifiable risk factor in atherosclerosis with a complex association with inflammation.OBJECTIVE:
In the present study, the association between low-density lipoprotein cholesterol (LDL-C) and interleukin 17A (IL-17A), as an inflammatory cytokine, was investigated. In addition to IL-17A, serum levels of interleukin 23 (IL-23) and transforming growth factor ß (TGF-ß), as effective cytokines in T helper 17 cell (Th17) development, were also determined.METHOD:
Cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA) in healthy subjects with LDL-C<130 versus LDL-C=>130 mg/dL.RESULTS:
Although IL-17A is an inflammatory cytokine and a positive association between its levels and LDL-C is expected, the data obtained in this study provide support for a reverse association (p<0.05).CONCLUSION:
Inflammation plays a major role in atherosclerosis development; however, various inflammatory components involved in atherosclerosis assert their own unique association with hypercholesterolemia.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Risk_factors_studies
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article