Advanced Photonic Sensors Based on Interband Cascade Lasers for Real-Time Mouse Breath Analysis.
ACS Sens
; 3(9): 1743-1749, 2018 09 28.
Article
em En
| MEDLINE
| ID: mdl-30074387
ABSTRACT
A multiparameter gas sensor based on distributed feedback interband cascade lasers emitting at 4.35 µm and ultrafast electro-spun luminescence oxygen sensors has been developed for the quantification and continuous monitoring of 13CO2/12CO2 isotopic ratio changes and oxygen in exhaled mouse breath samples. Mid-infrared absorption spectra for quantitatively monitoring the enrichment of 13CO2 levels were recorded in a miniaturized dual-channel substrate-integrated hollow waveguide using balanced ratiometric detection, whereas luminescence quenching was used for synchronously detecting exhaled oxygen levels. Allan variance analysis verified a CO2 measurement precision of 1.6 during a 480 s integration time. Routine online monitoring of exhaled mouse breath was performed in 14 mechanically ventilated and instrumented mice and demonstrated the feasibility of online isotope-selective exhaled breath analysis within microliters of probed gas samples using the reported combined sensor platform.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Testes Respiratórios
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Dióxido de Carbono
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Lasers
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article