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Extracellular Vesicles Secreted by Human Adipose-derived Stem Cells (hASCs) Improve Survival Rate of Rats with Acute Liver Failure by Releasing lncRNA H19.
Jin, Yinpeng; Wang, Junyi; Li, Hongchao; Gao, Shane; Shi, Rongfeng; Yang, Danjing; Wang, Xianli; Wang, Xi; Zhu, Liang; Wang, Xiaojin; Chen, Chengwei; Ning, Ke; Gao, Zhengliang; Xu, Jun; Fu, Qingchun.
Afiliação
  • Jin Y; Shanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China. Electronic address: 1182008211@qq.com.
  • Wang J; Shanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
  • Li H; Shanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
  • Gao S; East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
  • Shi R; Department of Interventional & Vascular Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, PR China.
  • Yang D; East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
  • Wang X; Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, PR China.
  • Wang X; Shanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China.
  • Zhu L; East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China.
  • Wang X; Shanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
  • Chen C; Shanghai Liver Diseases Research Center, The 85th Hospital of PLA, Shanghai 200235, PR China.
  • Ning K; Department of Neuroscience, Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.
  • Gao Z; East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China. Electronic address: zhengliang_gao@tongji.edu.cn.
  • Xu J; East Hospital, Tongji University School of Medicine, Shanghai 200120, PR China. Electronic address: xunymc2000@yahoo.com.
  • Fu Q; Shanghai Public Health Clinical Center, Fudan University, Jinshan, Shanghai 201508, PR China. Electronic address: qufu85@163.com.
EBioMedicine ; 34: 231-242, 2018 Aug.
Article em En | MEDLINE | ID: mdl-30077720
It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown by the improvement of the survival rate by >70% compared to controls. Gene sequencing of rat liver revealed an increase in human long-chain non-coding RNA (lncRNA) H19 after hASC-derived EVs transplantation. When the H19 coding sequence was silenced in hASCs and EVs were then collected for treatment of rats with liver failure, we saw a decrease in the survival rate to 40%, compared to treatment with EVs generated from non-silenced hASCs. These data indicate that lncRNA H19 may be a potential therapeutic target for the treatment of liver failure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Falência Hepática Aguda / RNA Longo não Codificante / Vesículas Extracelulares Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Falência Hepática Aguda / RNA Longo não Codificante / Vesículas Extracelulares Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article