Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit.

Meade, Nathan; Furey, Colleen; Li, Hua; Verma, Rita; Chai, Qingqing; Rollins, Madeline G; DiGiuseppe, Stephen; Naghavi, Mojgan H; Walsh, Derek

Meade, Nathan; Furey, Colleen; Li, Hua; Verma, Rita; Chai, Qingqing; Rollins, Madeline G; DiGiuseppe, Stephen; Naghavi, Mojgan H; Walsh, Derek.

Afiliação

Meade N; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Furey C; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Li H; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Verma R; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Chai Q; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Rollins MG; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
DiGiuseppe S; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Naghavi MH; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Walsh D; Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: derek.walsh@northwestern.edu.

Cell ; 174(5): 1143-1157.e17, 2018 08 23.

Article em En | MEDLINE | ID: mdl-30078703

Assuntos

Citosol/química; Poxviridae/metabolismo; Proteína Companheira de mTOR Insensível à Rapamicina/metabolismo; Proteína Regulatória Associada a mTOR/metabolismo; Proteínas de Transporte/metabolismo; Linhagem Celular; Citoplasma/metabolismo; Retículo Endoplasmático/metabolismo; Complexo de Golgi/metabolismo; Células HEK293; Homeostase; Humanos; Imunidade Inata; Interferons/metabolismo; Cinética; Fosforilação; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

STING; cGAS; innate immunity; interferon; mTOR; poxvirus; protein synthesis; sensor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Poxviridae / Citosol / Proteína Regulatória Associada a mTOR / Proteína Companheira de mTOR Insensível à Rapamicina Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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