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Interrogating the Relationship Between Schizotypy, the Catechol-O-Methyltransferase (COMT) Val158Met Polymorphism, and Neuronal Oscillatory Activity.
Steiner, Genevieve Z; Fernandez, Francesca M; Coles, Madilyn; Karamacoska, Diana; Barkus, Emma; Broyd, Samantha J; Solowij, Nadia; Watson, Owen T; Chiu, Christine L; Lind, Joanne M; Barry, Robert J.
Afiliação
  • Steiner GZ; NICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Penrith NSW, Australia.
  • Fernandez FM; Brain & Behavior Research Institute and School of Psychology, University of Wollongong, Wollongong NSW, Australia.
  • Coles M; Faculty of Science, Medicine and Health, University of Wollongong, Wollongong NSW, Australia.
  • Karamacoska D; School of Science, Australian Catholic University, Brisbane QLD, Australia.
  • Barkus E; School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong NSW, Australia.
  • Broyd SJ; NICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Penrith NSW, Australia.
  • Solowij N; NICM Health Research Institute and Translational Health Research Institute (THRI), Western Sydney University, Penrith NSW, Australia.
  • Watson OT; Brain & Behavior Research Institute and School of Psychology, University of Wollongong, Wollongong NSW, Australia.
  • Chiu CL; School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong NSW, Australia.
  • Lind JM; School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong NSW, Australia.
  • Barry RJ; School of Psychology and Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong NSW, Australia.
Cereb Cortex ; 29(7): 3048-3058, 2019 07 05.
Article em En | MEDLINE | ID: mdl-30084963
The COMT Val158Met polymorphism affects the availability of synaptic dopamine in the prefrontal cortex and has been widely studied as a genetic risk factor for psychosis. Schizotypy is associated with an increased risk of psychosis, with some studies implicating similar neurobiological mechanisms to schizophrenia. The present study sought to interrogate the link between the COMT Val158Met polymorphism and schizotypy using electroencephalogram (EEG) to identify neurophysiological mechanisms underpinning psychosis risk. Neurotypical (N = 91) adults were genotyped for the COMT Val158Met polymorphism, completed the Schizotypal Personality Questionnaire (SPQ), and had eyes open resting-state EEG recorded for 4 min. SPQ suspiciousness subscale scores were higher for individuals homozygous for Val/Val and Met/Met versus Val/Met genotypes. Delta, theta, alpha-2, beta-1, and beta-2 amplitudes were lower for Val/Val than Met/Met individuals. Lower theta amplitudes were correlated with higher total SPQ scores (P = 0.050), and multiple regression revealed that higher delta, and lower theta and beta-2 amplitudes (but not COMT genotype) best predicted total SPQ scores (P = 0.014). This study demonstrates the importance of COMT genotype in determining trait suspiciousness and EEG oscillatory activity. It also highlights relationships between dopaminergic alterations, EEG and schizotypy that are dissimilar to those observed in schizophrenia.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno da Personalidade Esquizotípica / Encéfalo / Catecol O-Metiltransferase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transtorno da Personalidade Esquizotípica / Encéfalo / Catecol O-Metiltransferase Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article