Dioxane-involving reaction for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines catalyzed by AgOTf.
Org Biomol Chem
; 16(33): 6070-6076, 2018 08 22.
Article
em En
| MEDLINE
| ID: mdl-30091433
ABSTRACT
Dioxane was found to be involved in the reaction of 2-(arylethynyl)benzaldehydes and 3-aminopyrazine-2-carbohydrazide, and underwent a ring-opening reaction catalyzed by AgOTf. This domino type procedure provided an efficient method for the synthesis of 3-aryl-1-(2-(vinyloxy)ethoxy)isoquinolines in good yields via the loss of a molecule of 3-aminopyrazine-2-carboxamide.
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01-internacional
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MEDLINE
Idioma:
En
Ano de publicação:
2018
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Article