Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A.

Shima, Kensuke; Ledig, Svea; Loeper, Nathalie; Schiefer, Andrea; Pfarr, Kenneth; Hoerauf, Achim; Graspeuntner, Simon; Rupp, Jan

Shima, Kensuke; Ledig, Svea; Loeper, Nathalie; Schiefer, Andrea; Pfarr, Kenneth; Hoerauf, Achim; Graspeuntner, Simon; Rupp, Jan.

Afiliação

Shima K; Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany. Electronic address: kensuke.shima@uksh.de.
Ledig S; Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Loeper N; Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Schiefer A; Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner sites Bonn-Cologne and Hamburg-Lübeck-Borstel, Germany.
Pfarr K; Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner sites Bonn-Cologne and Hamburg-Lübeck-Borstel, Germany.
Hoerauf A; Institute of Medical Microbiology, Immunology and Parasitology, University of Bonn, Bonn, Germany; German Center for Infection Research (DZIF), partner sites Bonn-Cologne and Hamburg-Lübeck-Borstel, Germany.
Graspeuntner S; Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany.
Rupp J; Department of Infectious Diseases and Microbiology, University of Lübeck, Lübeck, Germany; German Center for Infection Research (DZIF), partner sites Bonn-Cologne and Hamburg-Lübeck-Borstel, Germany.

Int J Antimicrob Agents ; 52(4): 523-524, 2018 Oct.

Article em En | MEDLINE | ID: mdl-30092271

Assuntos

Antibacterianos/farmacologia; Chlamydia trachomatis/efeitos dos fármacos; Chlamydia trachomatis/crescimento & desenvolvimento; RNA Polimerases Dirigidas por DNA/antagonistas & inibidores; Farmacorresistência Bacteriana; Lactonas/farmacologia; Rifampina/farmacologia; Animais; Antibacterianos/administração & dosagem; Antibacterianos/farmacocinética; Chlamydia trachomatis/isolamento & purificação; Células Epiteliais/microbiologia; Células HeLa; Humanos; Lactonas/administração & dosagem; Lactonas/farmacocinética; Camundongos; Testes de Sensibilidade Microbiana; Plasma/química

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Rifampina / RNA Polimerases Dirigidas por DNA / Chlamydia trachomatis / Farmacorresistência Bacteriana / Lactonas / Antibacterianos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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