Design, synthesis and pharmacological evaluation of new 3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives as potential antitumor agents.

Kuang, Wen-Bin; Huang, Ri-Zhen; Qin, Jiao-Lan; Lu, Xing; Qin, Qi-Pin; Zou, Bi-Qun; Chen, Zhen-Feng; Liang, Hong; Zhang, Ye

Kuang, Wen-Bin; Huang, Ri-Zhen; Qin, Jiao-Lan; Lu, Xing; Qin, Qi-Pin; Zou, Bi-Qun; Chen, Zhen-Feng; Liang, Hong; Zhang, Ye.

Afiliação

Kuang WB; School of Pharmacy, Guilin Medical University, Guilin 541004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
Huang RZ; Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Qin JL; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
Lu X; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
Qin QP; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China.
Zou BQ; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China; Department of Chemistry & Pharmaceutical Science, Guilin Normal College, Xinyi Road 15, Guangxi 541001, China.
Chen ZF; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China. Electronic address: chenzf@gxnu.edu.cn.
Liang H; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China. Electronic address: hliang@gxnu.edu.cn.
Zhang Y; School of Pharmacy, Guilin Medical University, Guilin 541004, China; State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmacy, Guangxi Normal University, Guilin 541004, China; Department of Chemistry & Pharmaceutical Science, Guilin No

Eur J Med Chem ; 157: 139-150, 2018 Sep 05.

Article em En | MEDLINE | ID: mdl-30092368

Assuntos

Antineoplásicos/farmacologia; Benzimidazóis/farmacologia; Desenho de Fármacos; Quinolonas/farmacologia; Antineoplásicos/síntese química; Antineoplásicos/química; Benzimidazóis/síntese química; Benzimidazóis/química; Ciclo Celular/efeitos dos fármacos; Linhagem Celular; Proliferação de Células/efeitos dos fármacos; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Humanos; Estrutura Molecular; Quinolonas/síntese química; Quinolonas/química; Relação Estrutura-Atividade; Proteína Supressora de Tumor p53/antagonistas & inibidores; Proteína Supressora de Tumor p53/biossíntese

Palavras-chave

3-(1H-benzimidazol-2-yl)quinolin-2(1H)-one derivatives; Action mechanism; Antitumor activity; Synthesis; p53

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzimidazóis / Desenho de Fármacos / Quinolonas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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