MicroRNA-942 mediates hepatic stellate cell activation by regulating BAMBI expression in human liver fibrosis.

Tao, Le; Xue, Dongying; Shen, Dongxiao; Ma, Wenting; Zhang, Jie; Wang, Xuefei; Zhang, Wei; Wu, Liu; Pan, Kai; Yang, Yanqin; Nwosu, Zeribe C; Dooley, Steven; Seki, Ekihiro; Liu, Cheng

Tao, Le; Xue, Dongying; Shen, Dongxiao; Ma, Wenting; Zhang, Jie; Wang, Xuefei; Zhang, Wei; Wu, Liu; Pan, Kai; Yang, Yanqin; Nwosu, Zeribe C; Dooley, Steven; Seki, Ekihiro; Liu, Cheng.

Afiliação

Tao L; Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai, 200062, China.
Xue D; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Shen D; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Ma W; Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai, 200062, China.
Zhang J; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Wang X; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Zhang W; Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai, 200062, China.
Wu L; Central Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, 164 Lanxi Rd, Shanghai, 200062, China.
Pan K; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Yang Y; Laboratory of Liver Disease, Department of Infectious Disease, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Nwosu ZC; Department of Pathology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200062, China.
Dooley S; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Seki E; Department of Medicine II, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Steven.Dooley@medma.uni-heidelberg.de.
Liu C; Division of Digestive and Liver Diseases, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, 90048, USA. Ekihiro.Seki@cshs.org.

Arch Toxicol ; 92(9): 2935-2946, 2018 09.

Article em En | MEDLINE | ID: mdl-30097701

Assuntos

Células Estreladas do Fígado/patologia; Cirrose Hepática/patologia; Proteínas de Membrana/genética; MicroRNAs/metabolismo; Células Cultivadas; Células Estreladas do Fígado/efeitos dos fármacos; Células Estreladas do Fígado/metabolismo; Humanos; Lipopolissacarídeos/farmacologia; Cirrose Hepática/genética; Proteínas de Membrana/metabolismo; Subunidade p50 de NF-kappa B/genética; Subunidade p50 de NF-kappa B/metabolismo; Receptor do Fator de Crescimento Transformador beta Tipo I/genética; Receptor do Fator de Crescimento Transformador beta Tipo I/metabolismo; Proteínas Smad Reguladas por Receptor/genética; Proteínas Smad Reguladas por Receptor/metabolismo; Fator de Crescimento Transformador beta1/farmacologia

Palavras-chave

HSCs; Liver fibrosis; TGF-ß signaling; Viral hepatitis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Células Estreladas do Fígado / Cirrose Hepática / Proteínas de Membrana Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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