[Association of TPH2 gene polymorphism with response to antidepressant treatment among ethnic Han Chinese population].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 35(4): 567-571, 2018 Aug 10.
Article
em Zh
| MEDLINE
| ID: mdl-30098258
ABSTRACT
OBJECTIVE:
To assess the association of TPH2 gene polymorphisms with the response or remission to selective serotonin reuptake inhibitors (SSRIs) drugs during treatment of major depressive disorder.METHODS:
For 304 patients receiving SSRIs treatment for major depression disorder, 3 single nucleotide polymorphisms (SNPs) (rs1007023, rs1023990 and rs4570625) in the TPH2 gene were genotyped by MALDI-TOF mass spectrometry using a MassArray Analyzer 4 system. HAMD-17 was adopted as the primary rating tool to evaluate the severity of depression on the baseline and at the end of 1st, 2nd, 4th and 6th week of treatment.RESULTS:
The frequency of GG genotype/G allele for rs4570625 differed significantly with the frequency of TT and GT genotypes/T allele between responders and non-responders (P=0.013 and 0.007, respectively). Genotypic and allelic frequencies of the other polymorphisms did not differ significantly between the two groups (P>0.05). No association of TPH2 gene polymorphism with remission was found with the 3 SNPs.CONCLUSION:
The polymorphisms of TPH2 gene may play an important role in response to antidepressant drug therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triptofano Hidroxilase
/
Inibidores Seletivos de Recaptação de Serotonina
/
Transtorno Depressivo Maior
/
Antidepressivos
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
País/Região como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article