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Synthesis of a 3'-C-ethynyl-ß-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides.
Hulpia, Fabian; Noppen, Sam; Schols, Dominique; Andrei, Graciela; Snoeck, Robert; Liekens, Sandra; Vervaeke, Peter; Van Calenbergh, Serge.
Afiliação
  • Hulpia F; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium.
  • Noppen S; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Schols D; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Andrei G; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Snoeck R; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Liekens S; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Vervaeke P; Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49, B-3000, Leuven, Belgium.
  • Van Calenbergh S; Laboratory for Medicinal Chemistry (Campus Heymans), Ghent University, Ottergemsesteenweg 460, B-9000, Gent, Belgium. Electronic address: serge.vancalenbergh@ugent.be.
Eur J Med Chem ; 157: 248-267, 2018 Sep 05.
Article em En | MEDLINE | ID: mdl-30098481

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Nucleosídeos de Purina / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Antineoplásicos / Nucleosídeos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Antivirais / Nucleosídeos de Purina / Bibliotecas de Moléculas Pequenas / Descoberta de Drogas / Antineoplásicos / Nucleosídeos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article