LipidFinder on LIPID MAPS: peak filtering, MS searching and statistical analysis for lipidomics.
Bioinformatics
; 35(4): 685-687, 2019 02 15.
Article
em En
| MEDLINE
| ID: mdl-30101336
ABSTRACT
SUMMARY:
We present LipidFinder online, hosted on the LIPID MAPS website, as a liquid chromatography/mass spectrometry (LC/MS) workflow comprising peak filtering, MS searching and statistical analysis components, highly customized for interrogating lipidomic data. The online interface of LipidFinder includes several innovations such as comprehensive parameter tuning, a MS search engine employing in-house customized, curated and computationally generated databases and multiple reporting/display options. A set of integrated statistical analysis tools which enable users to identify those features which are significantly-altered under the selected experimental conditions, thereby greatly reducing the complexity of the peaklist prior to MS searching is included. LipidFinder is presented as a highly flexible, extensible user-friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAPS website, long recognized as a leading global lipidomics portal. AVAILABILITY AND IMPLEMENTATION LipidFinder on LIPID MAPS is available at http//www.lipidmaps.org/data/LF.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
/
Bases de Dados Factuais
/
Lipídeos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article