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Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.
Ren, Weiwu; Pengelly, Robert; Farren-Dai, Marco; Shamsi Kazem Abadi, Saeideh; Oehler, Verena; Akintola, Oluwafemi; Draper, Jason; Meanwell, Michael; Chakladar, Saswati; Swiderek, Katarzyna; Moliner, Vicent; Britton, Robert; Gloster, Tracey M; Bennet, Andrew J.
Afiliação
  • Ren W; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Pengelly R; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Farren-Dai M; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Shamsi Kazem Abadi S; Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Oehler V; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.
  • Akintola O; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Draper J; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Meanwell M; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Chakladar S; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada.
  • Swiderek K; Department de Química Física i Analítica, Universitat Jaume I, 12071, Castellón, Spain.
  • Moliner V; Department de Química Física i Analítica, Universitat Jaume I, 12071, Castellón, Spain.
  • Britton R; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada. rbritton@sfu.ca.
  • Gloster TM; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK. tmg@st-andrews.ac.uk.
  • Bennet AJ; Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, V5A 1S6, Canada. bennet@sfu.ca.
Nat Commun ; 9(1): 3243, 2018 08 13.
Article em En | MEDLINE | ID: mdl-30104598
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Carbaçúcares / Glicosídeo Hidrolases Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores Enzimáticos / Carbaçúcares / Glicosídeo Hidrolases Idioma: En Ano de publicação: 2018 Tipo de documento: Article