Neutrophils and neutrophil-lymphocyte ratio: Inflammatory markers associated with intimal-media thickness of atherosclerosis.
Thromb Res
; 170: 45-52, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30118867
ABSTRACT
INTRODUCTION:
Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L. This study explored the respective effects of NEU and N/L on AS and intimal, media thickness. MATERIALS ANDMETHODS:
The χ2, Spearman's rho test, and multiple linear regression were implemented to analyze the relevance between blood parameters and intimal-media thickness. The potential factors, affecting non-depression time (NDT), is identified by univariate Cox regression. ROC curve was performed to determine the ability of blood parameters to predict intimal-media thickness. Immunohistochemistry was implemented. RESULTS ANDCONCLUSION:
Based on χ2, Spearman's rho test and multiple linear regression, NEU is related with intimal thickness (Pâ¯<â¯0.05). Furthermore, NEU can predict the intimal thickness through the ROC curve. What's more, N/L is a risk factor of carotid media thickness (Pâ¯<â¯0.05) by the Spearman's rho test, and is also correlated with poor NDT (Pâ¯<â¯0.05) based on univariate Cox proportional regression analysis. Through ROC curve, N/L can predict the carotid media thickness. The carotid atherosclerotic endarterium is richest in macrophagocytes, and the arrangement of endotheliocytes is disordered. In summary, the increased NEU and N/L respectively have a strong correlation and precise predictability for carotid intimal and media thickness of atherosclerosis.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos
/
Aterosclerose
/
Espessura Intima-Media Carotídea
/
Inflamação
/
Neutrófilos
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article