LRRK1 regulation of actin assembly in osteoclasts involves serine 5 phosphorylation of L-plastin.

Si, Mingjue; Goodluck, Helen; Zeng, Canjun; Pan, Songqin; Todd, Elizabeth M; Morley, Sharon Celeste; Qin, Xuezhong; Mohan, Subburaman; Xing, Weirong

Si, Mingjue; Goodluck, Helen; Zeng, Canjun; Pan, Songqin; Todd, Elizabeth M; Morley, Sharon Celeste; Qin, Xuezhong; Mohan, Subburaman; Xing, Weirong.

Afiliação

Si M; Department of Radiology, Shanghai Ninth People's Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Goodluck H; Department of Medicine, Loma Linda University, Loma Linda, California.
Zeng C; Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California.
Pan S; Musculoskeletal Disease Center, Jerry L. Pettis Memorial VA Medical Center, Loma Linda, California.
Todd EM; Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Morley SC; Proteomics Core Facility, University of California, Riverside, California.
Qin X; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Mohan S; Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Xing W; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri.

J Cell Biochem ; 119(12): 10351-10357, 2018 12.

Article em En | MEDLINE | ID: mdl-30136304

Assuntos

Actinas/genética; Glicoproteínas de Membrana/genética; Proteínas dos Microfilamentos/genética; Osteopetrose/genética; Proteínas Serina-Treonina Quinases/genética; Animais; Osso Esponjoso/crescimento & desenvolvimento; Osso Esponjoso/metabolismo; Citoesqueleto/genética; Humanos; Camundongos; Camundongos Knockout; Osteoclastos/metabolismo; Osteoclastos/patologia; Osteopetrose/patologia; Fosforilação/genética; Ligação Proteica; Proteínas Serina-Treonina Quinases/deficiência; Serina/genética; Transdução de Sinais/genética

Palavras-chave

L-plastin; Lrrk1; osteoclast; protein kinase; serine phosphorylation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteopetrose / Glicoproteínas de Membrana / Actinas / Proteínas Serina-Treonina Quinases / Proteínas dos Microfilamentos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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