Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosis.

Kohan-Ghadr, Hamid-Reza; Kilburn, Brian A; Kadam, Leena; Johnson, Eugenia; Kolb, Bradley L; Rodriguez-Kovacs, Javier; Hertz, Michael; Armant, D Randall; Drewlo, Sascha

Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosis.

Kohan-Ghadr, Hamid-Reza; Kilburn, Brian A; Kadam, Leena; Johnson, Eugenia; Kolb, Bradley L; Rodriguez-Kovacs, Javier; Hertz, Michael; Armant, D Randall; Drewlo, Sascha.

Afiliação

Kohan-Ghadr HR; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Kilburn BA; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Kadam L; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Johnson E; Department of Obstetrics, Gynecology and Reproductive Biology, College of Human Medicine, Michigan State University, Grand Rapids, Michigan, USA.
Kolb BL; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Rodriguez-Kovacs J; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Hertz M; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Armant DR; Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, Michigan, USA.
Drewlo S; Department of Anatomy and Cell Biology, Wayne State University School of Medicine, Detroit, Michigan, USA.

Biol Reprod ; 100(2): 479-494, 2019 02 01.

Article em En | MEDLINE | ID: mdl-30137220

Assuntos

Antioxidantes/farmacologia; Apoptose/fisiologia; Rosiglitazona/farmacologia; Trofoblastos/fisiologia; Caspase 3/genética; Caspase 3/metabolismo; Caspase 9/genética; Caspase 9/metabolismo; Catalase/genética; Catalase/metabolismo; Linhagem Celular Tumoral; Sobrevivência Celular; Coriocarcinoma/metabolismo; Feminino; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Mitocôndrias; Placenta/metabolismo; Gravidez; Espécies Reativas de Oxigênio/metabolismo; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Técnicas de Cultura de Tecidos

Palavras-chave

PPARÎ³; human placenta; hypoxia; oxidative stress; preeclampsia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Trofoblastos / Apoptose / Rosiglitazona / Antioxidantes Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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