Non-Directed Cross-Dehydrogenative (Hetero)arylation of Allylic C(sp3 )-H bonds enabled by C-H Activation.
Angew Chem Int Ed Engl
; 57(46): 15248-15252, 2018 11 12.
Article
em En
| MEDLINE
| ID: mdl-30152920
ABSTRACT
Herein, we report the selective, non-directed and cross-dehydrogenative coupling of allylic C(sp3 )-H bonds with C(sp2 )-H bonds of (hetero)arenes. The methodology employs olefins and (hetero)arenes which are abundantly available chemical feedstocks, and could be applied in late-stage functionalization reactions of pharmaceuticals. Furthermore, the system exclusively delivers the allylic C-C coupling products highlighting the preservation of the olefin substitution pattern for further derivatization.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article