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Pumilacidins from the Octocoral-Associated Bacillus sp. DT001 Display Anti-Proliferative Effects in Plasmodium falciparum.
Torres-Mendoza, Daniel; Coronado, Lorena M; Pineda, Laura M; Guzmán, Héctor M; Dorrestein, Pieter C; Spadafora, Carmenza; Gutiérrez, Marcelino.
Afiliação
  • Torres-Mendoza D; Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Panama, Apartado 0843-01103, Panama. dtorres@indicasat.org.pa.
  • Coronado LM; Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India. dtorres@indicasat.org.pa.
  • Pineda LM; Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Panama, Apartado 0843-01103, Panama. lcoronado@indicasat.org.pa.
  • Guzmán HM; Centro de Biología Celular y Molecular de Enfermedades, INDICASAT AIP, Panama, Apartado 0843-01103, Panama. lpineda@indicasat.org.pa.
  • Dorrestein PC; Smithsonian Tropical Research Institute, Balboa, Ancon P.O. Box 0843-03092, Panama. guzmanh@si.edu.
  • Spadafora C; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 92093, USA. pdorrestein@ucsd.edu.
  • Gutiérrez M; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. pdorrestein@ucsd.edu.
Molecules ; 23(9)2018 Aug 29.
Article em En | MEDLINE | ID: mdl-30158478
ABSTRACT
Chemical examination of the octocoral-associated Bacillus species (sp.) DT001 led to the isolation of pumilacidins A (1) and C (2). We investigated the effect of these compounds on the viability of Plasmodium falciparum and the mechanism of pumilacidin-induced death. The use of inhibitors of protein kinase C (PKC) and phosphoinositide 3-kinase (PI3K) was able to prevent the effects of pumilacidins A and C. The results indicated also that pumilacidins inhibit parasite growth via mitochondrial dysfunction and decreased cytosolic Ca2+.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Plasmodium falciparum / Bacillus / Antimaláricos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Plasmodium falciparum / Bacillus / Antimaláricos Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article