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[Tumour assessment criteria for immune checkpoint inhibitors]. / Critères d'évaluation de la réponse tumorale aux inhibiteurs des points de contrôle immunitaire.
Wasielewski, E; Cortot, A B.
Afiliação
  • Wasielewski E; Service de pneumologie et oncologie thoracique, université de Lille, hôpital Calmette, OncoLille, CHRU de Lille, boulevard Professeur-Jules-Leclercq, 59037 Lille, France.
  • Cortot AB; Service de pneumologie et oncologie thoracique, université de Lille, hôpital Calmette, OncoLille, CHRU de Lille, boulevard Professeur-Jules-Leclercq, 59037 Lille, France. Electronic address: alexis.cortot@chru-lille.fr.
Rev Mal Respir ; 35(8): 828-845, 2018 Oct.
Article em Fr | MEDLINE | ID: mdl-30166076
The development of immune checkpoint inhibitors in thoracic oncology has led to a reconsideration of the rules for radiological tumor assessment. The RECIST criteria are widely used for the assessment of conventional treatments but are not suitable for anti-tumoral immunotherapy. The mechanism of action of this new class of drugs may induce specific patterns of response, which are not fully assessed by the RECIST criteria. Several new criteria have been proposed to better detect these patterns of response. The changes usually include confirmation of progression, new ways of assessing new lesions, and a larger role for clinical assessment. Nevertheless, harmonization and validation of these criteria remains indispensable. In this review, we will detail the different criteria that are currently available, and discuss their strengths and weaknesses.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Antineoplásicos Imunológicos / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: Fr Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Proteínas Quinases / Pontos de Checagem do Ciclo Celular / Antineoplásicos Imunológicos / Imunoterapia / Neoplasias Limite: Animals / Humans Idioma: Fr Ano de publicação: 2018 Tipo de documento: Article