Vaccinating against Acne: Benefits and Potential Pitfalls.
J Invest Dermatol
; 138(11): 2304-2306, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30170784
ABSTRACT
Acne vulgaris is treated with antibiotics and retinoids, but side effects are numerous. Novel safe and efficient therapies are still needed. Wang et al. demonstrate that the secreted virulence factor Christie-Atkins-Munch-Peterson factor 2 from Propionibacterium acnes, a bacterium involved in acne pathogenesis, promotes inflammatory responses. This proinflammatory property could be inhibited by antibodies to Christie-Atkins-Munch-Peterson factor 2, suggesting Christie-Atkins-Munch-Peterson factor 2 as a candidate target in acne vaccination. This work supports the concept of acne immunotherapy, but questions about selection of target antigens remain open.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propionibacterium acnes
/
Acne Vulgar
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article