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Methods for determining key components in a mathematical model for tumor-immune dynamics in multiple myeloma.
Gallaher, Jill; Larripa, Kamila; Renardy, Marissa; Shtylla, Blerta; Tania, Nessy; White, Diana; Wood, Karen; Zhu, Li; Passey, Chaitali; Robbins, Michael; Bezman, Natalie; Shelat, Suresh; Jay Cho, Hearn; Moore, Helen.
Afiliação
  • Gallaher J; H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA. Electronic address: jill.gallaher@moffitt.org.
  • Larripa K; Department of Mathematics, Humboldt State University, Arcata, CA 95521, USA. Electronic address: kamila.larripa@humboldt.edu.
  • Renardy M; Department of Mathematics, The Ohio State University, Columbus, OH 43210, USA; Current affiliation: Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: renardy@umich.edu.
  • Shtylla B; Mathematics Department, Pomona College, Claremont, CA 91711, USA. Electronic address: shtyllab@pomona.edu.
  • Tania N; Department of Mathematics and Statistics, Smith College, Northampton, MA 01063,USA. Electronic address: ntania@smith.edu.
  • White D; Department of Mathematics, Clarkson University, Potsdam, NY 13699, USA. Electronic address: dtwhite@clarkson.edu.
  • Wood K; Department of Mathematics, University of California at Irvine, Irvine, CA 92697, USA; Current affiliation: The Aerospace Corporation, El Segundo, CA 90245, USA. Electronic address: kewood@uci.edu.
  • Zhu L; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Princeton, NJ 08543, USA. Electronic address: li.zhu@bms.com.
  • Passey C; Clinical Pharmacology and Pharmacometrics, Bristol-Myers Squibb, Princeton, NJ 08543, USA; Current affiliation: Genmab, Monmouth Junction, NJ 08852, USA.
  • Robbins M; Hematology Medical Strategy, Bristol-Myers Squibb, Lawrence Township, NJ 08648, USA. Electronic address: michael.robbins@bms.com.
  • Bezman N; Immuno-Oncology Discovery, Bristol-Myers Squibb, Redwood City, CA 94063, USA. Electronic address: natalie.bezman@bms.com.
  • Shelat S; Oncology Clinical Development, Bristol-Myers Squibb, Lawrence Township, NJ 08648, USA. Electronic address: suresh.shelat@bms.com.
  • Jay Cho H; Tisch Cancer Institute, Mt. Sinai School of Medicine, New York, NY 10029, USA. Electronic address: hearn.jay.cho@mssm.edu.
  • Moore H; Bristol-Myers Squibb, Princeton, NJ 08543, USA; Current affiliation: AstraZeneca, Waltham, MA 02451, USA. Electronic address: dr.helen.moore@gmail.com.
J Theor Biol ; 458: 31-46, 2018 12 07.
Article em En | MEDLINE | ID: mdl-30172689
ABSTRACT
In this work, we analyze a mathematical model we introduced previously for the dynamics of multiple myeloma and the immune system. We focus on four main aspects (1) obtaining and justifying ranges and values for all parameters in the model; (2) determining a subset of parameters to which the model is most sensitive; (3) determining which parameters in this subset can be uniquely estimated given certain types of data; and (4) exploring the model numerically. Using global sensitivity analysis techniques, we found that the model is most sensitive to certain growth, loss, and efficacy parameters. This analysis provides the foundation for a future application of the model prediction of optimal combination regimens in patients with multiple myeloma.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Modelos Imunológicos / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Modelos Imunológicos / Mieloma Múltiplo Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article