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3D porous collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite composite scaffolds for bone tissue engineering.
Türk, S; Altinsoy, I; Çelebi Efe, G; Ipek, M; Özacar, M; Bindal, C.
Afiliação
  • Türk S; Sakarya University, Biomedical, Magnetic and Semi Conductive Materials Research Center (BIMAS-RC), Esentepe Campus, 54187, Sakarya, Turkey.
  • Altinsoy I; Sakarya University, Faculty of Engineering, Department of Metallurgy and Materials Engineering, Esentepe Campus, 54187, Sakarya, Turkey.
  • Çelebi Efe G; Sakarya University, Biomedical, Magnetic and Semi Conductive Materials Research Center (BIMAS-RC), Esentepe Campus, 54187, Sakarya, Turkey; Sakarya University, Faculty of Engineering, Department of Metallurgy and Materials Engineering, Esentepe Campus, 54187, Sakarya, Turkey.
  • Ipek M; Sakarya University, Faculty of Engineering, Department of Metallurgy and Materials Engineering, Esentepe Campus, 54187, Sakarya, Turkey.
  • Özacar M; Sakarya University, Biomedical, Magnetic and Semi Conductive Materials Research Center (BIMAS-RC), Esentepe Campus, 54187, Sakarya, Turkey; Sakarya University, Science & Arts Faculty, Department of Chemistry, Sakarya 54187, Turkey.
  • Bindal C; Sakarya University, Biomedical, Magnetic and Semi Conductive Materials Research Center (BIMAS-RC), Esentepe Campus, 54187, Sakarya, Turkey; Sakarya University, Faculty of Engineering, Department of Metallurgy and Materials Engineering, Esentepe Campus, 54187, Sakarya, Turkey. Electronic address: bin
Mater Sci Eng C Mater Biol Appl ; 92: 757-768, 2018 Nov 01.
Article em En | MEDLINE | ID: mdl-30184804
In this study, we describe new collagen/functionalized multiwalled carbon nanotube/chitosan/hydroxyapatite (Col/f-MWCNT/CS/HA) composite scaffolds which were fabricated by freezing (-40 °C at 0.9 °C/min) and lyophilization (48 h, 0 °C and 200 mtorr). The compressive stresses (from 523 to 1112 kPa), swelling (from 513.9 ±â€¯27 to 481.05 ±â€¯25%), porosity (from 98 ±â€¯0.15 to 95.7 ±â€¯0.1%), contact angle (from 87.8 to 76.7°) properties examined before and after biomineralization for comparison 3D porous Col, CS, Col/f-MWCNT and Col/f-MWCNT/CS scaffolds. Biomineralization was performed by biomimetic method in concentrated SBF (10 × SBF, at 37 °C and 6.5 pH). XRD, SEM, EDS, FTIR, TGA, Optical microscopy and BET results showed that compared to Col, CS and Col/f-MWCNT scaffolds, Col/f-MWCNT/CS scaffolds had higher in vitro bioactivity, large surface area (11.746 m2/g) and a good pore volume (0.026 cc/g), interconnected porous microstructure (with 20-350 µm pore size) and incorporates the advantageous properties of both Col, f-MWCNT, CS and HA. Finally, the methyl thiazolyl tetrazolium (MTT) assay was performed to evaluate scaffolds cytotoxicity which showed that Col/f-MWCNT/CS scaffolds have the best biocompatibility.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osso e Ossos / Teste de Materiais / Durapatita / Engenharia Tecidual / Nanotubos de Carbono / Alicerces Teciduais Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osso e Ossos / Teste de Materiais / Durapatita / Engenharia Tecidual / Nanotubos de Carbono / Alicerces Teciduais Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article