The possible role of benzodiazepine receptors in morphine analgesia.
Pharmacol Biochem Behav
; 25(1): 215-7, 1986 Jul.
Article
em En
| MEDLINE
| ID: mdl-3018793
ABSTRACT
Diazepam within its therapeutic dose range, was shown to have no effect on nociception, but was shown to antagonize the analgesic action of morphine. This antagonism was found to be statistically significant at 0.5 mg/kg diazepam. To elucidate the mechanism of this inhibitory action of diazepam against morphine analgesia, Ro 15-1788, the specific antagonist of benzodiazepine receptors was used. As a result, Ro 15-1788 was found to partially reverse the inhibitory action of diazepam against morphine analgesia. This overall interaction between the supramolecular GABA receptor complex and morphine is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Receptores de GABA-A
/
Diazepam
/
Morfina
Limite:
Animals
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article