Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal.
PLoS Genet
; 14(9): e1007650, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-30188897
ABSTRACT
Adaptive evolution in humans has rarely been characterized for its whole set of components, i.e. selective pressure, adaptive phenotype, beneficial alleles and realized fitness differential. We combined approaches for detecting polygenic adaptations and for mapping the genetic bases of physiological and fertility phenotypes in approximately 1000 indigenous ethnically Tibetan women from Nepal, adapted to high altitude. The results of genome-wide association analyses and tests for polygenic adaptations showed evidence of positive selection for alleles associated with more pregnancies and live births and evidence of negative selection for those associated with higher offspring mortality. Lower hemoglobin level did not show clear evidence for polygenic adaptation, despite its strong association with an EPAS1 haplotype carrying selective sweep signals.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Seleção Genética
/
Haplótipos
/
Herança Multifatorial
/
Povo Asiático
/
Aclimatação
Limite:
Adult
/
Aged
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Aged80
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Female
/
Humans
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Middle aged
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article