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A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels.
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F; Feufer, Arne P; Marullo, Letizia; Mägi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga.
Afiliação
  • Rosticci M; Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Pervjakova N; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Kaakinen M; Department of Biotechnology, Institute of Molecular & Cell Biology, University of Tartu, Tartu, Estonia.
  • Cicero AF; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Feufer AP; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Marullo L; Pharmacology & Therapeutics, Division of Experimental Medicine, Department of Medicine, Imperial College London, London, UK.
  • Mägi R; Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Fischer K; Institute of Bioinformatics & Systems Biology, Helmholtz Zentrum München, München, Germany.
  • Jiang L; Department of Life Sciences & Biotechnology, University of Ferrara, Ferrara, Italy.
  • D'Addato S; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Rizzoli E; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
  • Massimo G; Genomics of Common Disease, Division of Diabetes, Endocrinology & Metabolism, Department of Medicine, Imperial College London, London, UK.
  • Giovannini M; Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Angelini S; Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Hrelia P; Department of Pharmacy & Biotechnology, Alma Mater Studiorum University of Bologna, Italy.
  • Scapoli C; Medicine & Surgery Sciences Department, Alma Mater Studiorum University of Bologna, Bologna, Italy.
  • Borghi C; Department of Pharmacy & Biotechnology, Alma Mater Studiorum University of Bologna, Italy.
  • Prokopenko I; Department of Pharmacy & Biotechnology, Alma Mater Studiorum University of Bologna, Italy.
Biomark Med ; 13(11): 931-940, 2019 08 01.
Article em En | MEDLINE | ID: mdl-30191727
ABSTRACT

Aim:

The aim of the study was to explore the effects of variants at HMGCR-KIF6loci on a range of cardio-metabolic phenotypes.

Methods:

We analyzed the range of variants within Genetics in Brisighella Health Study and KIF6 genes using an additive genetic model on 18 cardiometabolic phenotypes in a sample of 1645 individuals from the Genetics in Brisighella Health Study and replicated in 10,662 individuals from the Estonian Genome Center University of Tartu.

Results:

We defined directly the effects of rs3846662C>A at HMGCR on apoB levels. The analysis also confirmed effects of on low-density lipoprotein-cholesterol and total cholesterol levels. Variants in KIF6 gene did not reveal any associations with cardiometabolic phenotypes.

Conclusion:

This study highlights effect of HMGCR locus on assay-determined apoB levels, an infrequent measure of blood lipids in large studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Apolipoproteína B-100 / Hidroximetilglutaril-CoA Redutases Tipo de estudo: Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Apolipoproteína B-100 / Hidroximetilglutaril-CoA Redutases Tipo de estudo: Systematic_reviews Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2019 Tipo de documento: Article