Disproportionate feedback interactions govern cell-type specific proliferation in mammalian cells.
FEBS Lett
; 592(19): 3248-3263, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30192983
ABSTRACT
In mammalian cells, the decision to maintain quiescence over proliferation commitment during G1 -S transition depends on more than one intertwined feedback interaction and is highly cell-type dependent. However, the precise role played by these individual feedback regulations in organizing such diverse proliferation dynamics is still poorly understood. Herein, we propose a predictive mathematical model of G1 -S transition in mammalian cells that reconciles distinct single-cell experimental observations in a cell-type specific manner. The model analysis reveals that the feedback motifs responsible for the G1 -S transition act in a disparate fashion to organize the cell-type specific proliferation response. Importantly, the proposed model can be effectively tuned to gain insights into the proliferation commitment of diverse mammalian cell types and can find wide applicability.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ciclo Celular
/
Retroalimentação Fisiológica
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Proliferação de Células
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Fatores de Transcrição E2F
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article