Stereoisomeric guaiacylglycerol-ß-coniferyl aldehyde ether induces distinctive apoptosis by downregulation of MEK/ERK pathway in hepatocellular carcinoma cells.

Yao, Guo-Dong; Wang, Jie; Song, Xiao-Yu; Zhou, Le; Lou, Li-Li; Zhao, Wen-Yu; Lin, Bin; Huang, Xiao-Xiao; Song, Shao-Jiang

Yao, Guo-Dong; Wang, Jie; Song, Xiao-Yu; Zhou, Le; Lou, Li-Li; Zhao, Wen-Yu; Lin, Bin; Huang, Xiao-Xiao; Song, Shao-Jiang.

Afiliação

Yao GD; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Wang J; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Song XY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhou L; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lou LL; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Zhao WY; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Lin B; School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China.
Huang XX; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China; Chinese People's Liberation Army 210 Hospital, Dalian 116021, People's Republic of China.
Song SJ; School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China. Electronic address: songsj99@163.com.

Bioorg Chem ; 81: 382-388, 2018 12.

Article em En | MEDLINE | ID: mdl-30196208

Assuntos

Acroleína/análogos & derivados; Antineoplásicos/farmacologia; Apoptose/efeitos dos fármacos; Carcinoma Hepatocelular/tratamento farmacológico; Guaifenesina/farmacologia; Neoplasias Hepáticas/tratamento farmacológico; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Acroleína/química; Acroleína/farmacologia; Antineoplásicos/química; Carcinoma Hepatocelular/metabolismo; Carcinoma Hepatocelular/patologia; Linhagem Celular Tumoral; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Guaifenesina/análogos & derivados; Humanos; Neoplasias Hepáticas/metabolismo; Neoplasias Hepáticas/patologia; Estereoisomerismo

Palavras-chave

8-O-4'-type neolignans; Apoptosis; Enantiomers; Epimers; Guaiacylglycerol-ß-coniferyl aldehyde ether; Hepatocellular carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acroleína / Apoptose / Carcinoma Hepatocelular / Sistema de Sinalização das MAP Quinases / Guaifenesina / Neoplasias Hepáticas / Antineoplásicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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