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Novel N-1 substituted fluoroquinolones inhibit human topoisomerase I activity and exhibit anti-proliferative activity.
Oppegard, Lisa M; Delgado, Justine L; Kulkarni, Chaitanya A; Towle, Tyrell R; Hart, Delaney E; Williams, Bridget P; Lentz, Sarah R C; Norris, Beverly J; Flory, Craig M; Schumacher, Robert J; Murry, Daryl J; Kerns, Robert J; Hiasa, Hiroshi.
Afiliação
  • Oppegard LM; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Delgado JL; College of Undergraduate Health Sciences, Northwestern Health Sciences University, Bloomington, MN, 55431, USA.
  • Kulkarni CA; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Towle TR; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Hart DE; Division of Medicinal and Natural Products Chemistry, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
  • Williams BP; MedPharm Holdings, Denver, CO, 80239, USA.
  • Lentz SRC; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Norris BJ; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Flory CM; Department of Pharmacology, University of Minnesota Medical School, 6-120 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
  • Schumacher RJ; Center for Translational Medicine, University of Minnesota Academic Health Center, 515 Delaware Street SE, Room 2-191, Minneapolis, MN, 55455, USA.
  • Murry DJ; Center for Translational Medicine, University of Minnesota Academic Health Center, 515 Delaware Street SE, Room 2-191, Minneapolis, MN, 55455, USA.
  • Kerns RJ; Center for Translational Medicine, University of Minnesota Academic Health Center, 515 Delaware Street SE, Room 2-191, Minneapolis, MN, 55455, USA.
  • Hiasa H; The Division of Pharmaceutics and Translational Therapeutics, Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, 115 S Grand Ave., S321 Pharmacy Building, Iowa City, IA, 52242, USA.
Invest New Drugs ; 37(2): 378-383, 2019 04.
Article em En | MEDLINE | ID: mdl-30198058
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / DNA Topoisomerases Tipo I / Fluoroquinolonas / Inibidores da Topoisomerase I / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / DNA Topoisomerases Tipo I / Fluoroquinolonas / Inibidores da Topoisomerase I / Antineoplásicos Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article