[Secondary metabolites of Streptomyces sp. A1693].
Zhongguo Zhong Yao Za Zhi
; 43(16): 3301-3306, 2018 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-30200733
ABSTRACT
By means of various chromatographic methods such as Sephadex LH-20ï¼ODSï¼and semi-preparative HPLCï¼ten compounds were isolated from Streptomyces sp. A1693 and their structures were elucidated on the basis of spectroscopic data and physico-chemical methods. The compounds comprised 5 butenolidesï¼2 diketopiperazinesï¼and 3 antimycin antibiotics. The structures were identified as (5S)-5-(11-hydroxymethyloctyl)furan-2(5H)-one (1), (5S)-5-(11-hydroxy-11-methylheptyl)furan-2(5H)-one (2), (5S)-5-(11-methyl-12-oxooctyl) furan-2(5H)-one (3), (5S)-5-(11-hydroxy-11-methyloctyl)furan-2(5H)-one (4), (5S)-5-(11-hydroxy-12-methyloctyl)furan-2(5H)-oneï¼5ï¼ï¼cyclo-Phe-Val (6)ï¼cyclo-Phe-Ile (7)ï¼uranchimycin A (8)ï¼uranchimycin B (9)ï¼and deisovalerylblastomycin (10). Among themï¼1 was defined as a new compound. All the compounds didn't show the cytotoxic activity against A549 cell line (IC50>50 mg·L⻹).
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
/
Dicetopiperazinas
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article