Changes in biophysical characteristics of PFN1 due to mutation causing amyotrophic lateral sclerosis.

Nekouei, Mina; Ghezellou, Parviz; Aliahmadi, Atousa; Arjmand, Sareh; Kiaei, Mahmoud; Ghassempour, Alireza

Nekouei, Mina; Ghezellou, Parviz; Aliahmadi, Atousa; Arjmand, Sareh; Kiaei, Mahmoud; Ghassempour, Alireza.

Afiliação

Nekouei M; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
Ghezellou P; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
Aliahmadi A; Department of Biology, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
Arjmand S; Protein Research Center, Shahid Beheshti University, G.C., Evin, Tehran, Iran.
Kiaei M; Department of Pharmacology and Toxicology, Department of Neurology, Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA. mkiaei@uams.edu.
Ghassempour A; Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. a-ghassempour@sbu.ac.ir.

Metab Brain Dis ; 33(6): 1975-1984, 2018 12.

Article em En | MEDLINE | ID: mdl-30203378

Assuntos

Esclerose Lateral Amiotrófica/genética; Mutação/genética; Profilinas/química; Profilinas/genética; Agregados Proteicos/genética; Humanos; Estrutura Secundária de Proteína; Proteínas Recombinantes/química; Proteínas Recombinantes/genética

Palavras-chave

ALS; Actin binding domain; Aggregation; PFN1G118V; PFN1WT

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Profilinas / Agregados Proteicos / Esclerose Lateral Amiotrófica / Mutação Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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