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Mesoporous Bioactive Glasses Equipped with Stimuli-Responsive Molecular Gates for Controlled Delivery of Levofloxacin against Bacteria.
Polo, Lorena; Gómez-Cerezo, Natividad; García-Fernández, Alba; Aznar, Elena; Vivancos, José-Luis; Arcos, Daniel; Vallet-Regí, María; Martínez-Máñez, Ramón.
Afiliação
  • Polo L; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain.
  • Gómez-Cerezo N; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain, Av. Monforte de Lemos 3-5, 28029, Madrid, Spain.
  • García-Fernández A; CIBER de Bioingeniería Biomateriales y Nanomedicina (CIBER-BBN), Spain, Av. Monforte de Lemos 3-5, 28029, Madrid, Spain.
  • Aznar E; Departamento de Química en Ciencias Farmacéuticas, (Química Inorgánica y Bioinorgánica), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.
  • Vivancos JL; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain.
  • Arcos D; Departamento de Química en Ciencias Farmacéuticas, (Química Inorgánica y Bioinorgánica), Facultad de Farmacia, Universidad Complutense de Madrid, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.
  • Vallet-Regí M; Unidad Mixta UPV-CIPF de Investigación en Mecanismos de, Enfermedades y Nanomedicina, Universitat Politècnica de València, Centro de Investigación Príncipe Felipe, Carrer d'Eduardo Primo Yúfera 3, 46012, Valencia, Spain.
  • Martínez-Máñez R; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Camino de Vera s/n, 46022, Valencia, Spain.
Chemistry ; 24(71): 18944-18951, 2018 Dec 17.
Article em En | MEDLINE | ID: mdl-30203561
ABSTRACT
An increase of bone diseases incidence has boosted the study of ceramic biomaterials as potential osteo-inductive scaffolds. In particular, mesoporous bioactive glasses have demonstrated to possess a broad application in the bone regeneration field, due their osteo-regenerative capability and their ability to release drugs from the mesoporous structure. These special features have been studied as an option to fight against bone infection, which is one of the most common problems regarding bone regeneration therapies. In this work, a mesoporous bioglass functionalized with polyamines and capped with adenosine triphosphate (ATP) as the molecular gate was developed for the controlled release of the antibiotic levofloxacin. Phosphate bonds of ATP were hydrolyzed in the presence of acid phosphatase (APase), the concentration of which is significantly increased in bone infection due to the activation of bone resorption processes. The solid was characterized and tested successfully against bacteria. The final gated solid induced bacterial death only in the presence of acid phosphatase. Additionally, it was demonstrated that the solid is not toxic against human cells. The double function of the prepared material as a drug delivery system and bone regeneration enhancer confirms the possible development of a new approach in the tissue engineering field, in which controlled release of therapeutic agents can be finely tuned and, at the same time, osteoinduction is favored.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cerâmica / Substitutos Ósseos / Preparações de Ação Retardada / Escherichia coli / Infecções por Escherichia coli / Levofloxacino / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cerâmica / Substitutos Ósseos / Preparações de Ação Retardada / Escherichia coli / Infecções por Escherichia coli / Levofloxacino / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article