Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs.

Makino, Elena; Gutmann, Vanessa; Kosnopfel, Corinna; Niessner, Heike; Forschner, Andrea; Garbe, Claus; Sinnberg, Tobias; Schittek, Birgit

Makino, Elena; Gutmann, Vanessa; Kosnopfel, Corinna; Niessner, Heike; Forschner, Andrea; Garbe, Claus; Sinnberg, Tobias; Schittek, Birgit.

Afiliação

Makino E; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Gutmann V; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Kosnopfel C; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Niessner H; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Forschner A; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Garbe C; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Sinnberg T; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany.
Schittek B; Division of Dermatooncology, Department of Dermatology, University of Tübingen, Tübingen, Germany. birgit.schittek@med.uni-tuebingen.de.

Cell Death Dis ; 9(9): 930, 2018 09 11.

Article em En | MEDLINE | ID: mdl-30206212

Assuntos

Antineoplásicos/uso terapêutico; Carboplatina/uso terapêutico; Cisplatino/uso terapêutico; Melanoma/tratamento farmacológico; Inibidores de Proteínas Quinases/farmacologia; Proteína Tumoral p73/biossíntese; Linhagem Celular Tumoral; Quebras de DNA de Cadeia Dupla/efeitos dos fármacos; Reparo do DNA/fisiologia; Resistencia a Medicamentos Antineoplásicos/genética; Humanos; Melanoma/patologia; Paclitaxel/uso terapêutico; Estudos Retrospectivos; Proteína Supressora de Tumor p53/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carboplatina / Cisplatino / Inibidores de Proteínas Quinases / Proteína Tumoral p73 / Melanoma / Antineoplásicos Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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