Silencing of microRNA-375 affects immune function in mice with liver failure by upregulating astrocyte elevated gene-1 through reducing apoptosis of Kupffer cells.

Ke, Qing-Hong; Chen, Hai-Yong; He, Zeng-Lei; Lv, Zhen; Xu, Xiao-Feng; Qian, Yi-Gang; Zheng, Shu-Sen

Ke, Qing-Hong; Chen, Hai-Yong; He, Zeng-Lei; Lv, Zhen; Xu, Xiao-Feng; Qian, Yi-Gang; Zheng, Shu-Sen.

Afiliação

Ke QH; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Chen HY; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
He ZL; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Lv Z; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Xu XF; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Qian YG; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Zheng SS; Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, China.

J Cell Biochem ; 120(1): 253-263, 2019 01.

Article em En | MEDLINE | ID: mdl-30206980

Assuntos

Apoptose; Inativação Gênica; Células de Kupffer/metabolismo; Falência Hepática/metabolismo; Glicoproteínas de Membrana/genética; MicroRNAs/genética; Regulação para Cima/genética; Animais; Concanavalina A/farmacologia; Modelos Animais de Doenças; Interleucina-1beta/metabolismo; Interleucina-6/metabolismo; Falência Hepática/induzido quimicamente; Masculino; Glicoproteínas de Membrana/metabolismo; Camundongos; Camundongos Endogâmicos C57BL; MicroRNAs/metabolismo; Transfecção; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Kupffer cells; astrocyte elevated gene-1 (AEG-1); interleukin-1ß (IL-1ß); interleukin-6 (IL-6); liver failure; microRNA-375 (miR-375); targeted regulation; tumor necrosis factor-α (TNF-α)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Regulação para Cima / Falência Hepática / Apoptose / Inativação Gênica / MicroRNAs / Células de Kupffer Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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