NIX-mediated mitophagy protects against proteinuria-induced tubular cell apoptosis and renal injury.

Xu, Dan; Chen, Panpan; Wang, Bao; Wang, Yanzhe; Miao, Naijun; Yin, Fan; Cheng, Qian; Zhou, Zhuanli; Xie, Hongyan; Zhou, Li; Liu, Jun; Wang, Xiaoxia; Zent, Roy; Lu, Limin; Zhang, Wei

Xu, Dan; Chen, Panpan; Wang, Bao; Wang, Yanzhe; Miao, Naijun; Yin, Fan; Cheng, Qian; Zhou, Zhuanli; Xie, Hongyan; Zhou, Li; Liu, Jun; Wang, Xiaoxia; Zent, Roy; Lu, Limin; Zhang, Wei.

Afiliação

Xu D; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Chen P; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Wang B; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Wang Y; Department of Nephrology, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Miao N; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Yin F; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Cheng Q; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Zhou Z; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Xie H; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Zhou L; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Liu J; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.
Wang X; Department of Nephrology, Shanghai Tong Ren Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China.
Zent R; Department of Medicine, Vanderbilt University Medical Center , Nashville, Tennessee.
Lu L; Veterans Affairs Hospital , Nashville, Tennessee.
Zhang W; Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Fudan University , Shanghai , China.

Am J Physiol Renal Physiol ; 316(2): F382-F395, 2019 02 01.

Article em En | MEDLINE | ID: mdl-30207166

Assuntos

Albuminúria/metabolismo; Apoptose; Células Epiteliais/metabolismo; Túbulos Renais/metabolismo; Proteínas de Membrana/metabolismo; Mitocôndrias/metabolismo; Proteínas Mitocondriais/metabolismo; Mitofagia; Nefrose/metabolismo; Proteínas Proto-Oncogênicas/metabolismo; Proteínas Supressoras de Tumor/metabolismo; Adulto; Idoso; Idoso de 80 Anos ou mais; Albuminúria/genética; Albuminúria/patologia; Albuminúria/fisiopatologia; Animais; Estudos de Casos e Controles; Linhagem Celular; Modelos Animais de Doenças; Células Epiteliais/patologia; Feminino; Taxa de Filtração Glomerular; Humanos; Túbulos Renais/patologia; Túbulos Renais/fisiopatologia; Masculino; Proteínas de Membrana/genética; Camundongos Endogâmicos C57BL; Pessoa de Meia-Idade; Mitocôndrias/patologia; Proteínas Mitocondriais/genética; Nefrose/genética; Nefrose/patologia; Nefrose/fisiopatologia; Proteínas Proto-Oncogênicas/genética; Transdução de Sinais; Proteínas Supressoras de Tumor/genética; Adulto Jovem

Palavras-chave

NIX; apoptosis; mitophagy; proteinuria; renal tubule

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Proto-Oncogênicas / Apoptose / Proteínas Mitocondriais / Proteínas Supressoras de Tumor / Albuminúria / Células Epiteliais / Mitofagia / Túbulos Renais / Proteínas de Membrana / Mitocôndrias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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