HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection.

MacDuff, Donna A; Baldridge, Megan T; Qaqish, Arwa M; Nice, Timothy J; Darbandi, Azad D; Hartley, Victoria L; Peterson, Stefan T; Miner, Jonathan J; Iwai, Kazuhiro; Virgin, Herbert W

MacDuff, Donna A; Baldridge, Megan T; Qaqish, Arwa M; Nice, Timothy J; Darbandi, Azad D; Hartley, Victoria L; Peterson, Stefan T; Miner, Jonathan J; Iwai, Kazuhiro; Virgin, Herbert W.

Afiliação

MacDuff DA; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA dmacduff@uic.edu virgin@wustl.edu.
Baldridge MT; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA.
Qaqish AM; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nice TJ; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Darbandi AD; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA.
Hartley VL; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Peterson ST; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA.
Miner JJ; Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, Illinois, USA.
Iwai K; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Virgin HW; Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.

J Virol ; 92(23)2018 12 01.

Article em En | MEDLINE | ID: mdl-30209176

Assuntos

Infecções por Caliciviridae/virologia; Interferon Tipo I/metabolismo; Helicase IFIH1 Induzida por Interferon/metabolismo; Interferons/metabolismo; Norovirus/patogenicidade; Ubiquitina-Proteína Ligases/fisiologia; Animais; Infecções por Caliciviridae/genética; Infecções por Caliciviridae/metabolismo; Infecções por Caliciviridae/microbiologia; Células Cultivadas; Células Dendríticas/metabolismo; Células Dendríticas/microbiologia; Células Dendríticas/virologia; Fibroblastos/metabolismo; Fibroblastos/microbiologia; Fibroblastos/virologia; Genoma Viral; Fator Regulador 3 de Interferon/genética; Fator Regulador 3 de Interferon/metabolismo; Interferon Tipo I/genética; Helicase IFIH1 Induzida por Interferon/genética; Interferons/genética; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Microbiota; Norovirus/genética; Fosforilação; Interferon lambda

Palavras-chave

HOIL1; LUBAC; MDA5; interferons; norovirus; ubiquitination

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Interferon Tipo I / Interferons / Infecções por Caliciviridae / Norovirus / Ubiquitina-Proteína Ligases / Helicase IFIH1 Induzida por Interferon Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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