Alcohol intake and risk of rheumatoid arthritis: a Mendelian randomization study.
Z Rheumatol
; 78(8): 791-796, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-30209555
ABSTRACT
OBJECTIVE:
To examine whether alcohol intake is causally associated with rheumatoid arthritis (RA).METHODS:
We performed a two-sample Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW), weighted median, and MR-Egger regression methods. We used the publicly available summary statistics of alcohol intake frequency from the UK Biobank genome-wide association studies (GWASs; nâ¯= 336,965) as the exposure and a GWAS meta-analysis of 5539 autoantibody-positive RA patients and 20,169 controls as the outcome.RESULTS:
We selected 24 single nucleotide polymorphisms (SNPs) associated with alcohol intake frequency at genome-wide significance as instrumental variables (IVs) to improve inference, 16 of which were inversely associated with RA. The IVW method showed no evidence of a causal association between alcohol intake and RA (betaâ¯= 0.218, SEâ¯= 0.213, pâ¯= 0.306). The MR-Egger regression revealed that directional pleiotropy was unlikely to bias the result (interceptâ¯= 0.027, pâ¯= 0.292). The MR-Egger analysis and the weighted median approach showed no causal association between alcohol intake and RA (betaâ¯= -0.778, SEâ¯= 0.947, pâ¯= 0.420 and betaâ¯= -0.286, SEâ¯= 0.302, pâ¯= 0.344, respectively). Cochran's Q test did not indicate heterogeneity between IV estimates based on the individual variants, and results from a "leave-one-out" analysis demonstrated that no single SNP was driving the IVW point estimate.CONCLUSION:
The MR analysis does not support a causal inverse association between alcohol intake and RA occurrence.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Consumo de Bebidas Alcoólicas
/
Análise da Randomização Mendeliana
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article