Evaluation of the developmental toxicity of perfluorooctanesulfonate in the Anuran, Silurana tropicalis.
J Appl Toxicol
; 39(2): 365-374, 2019 02.
Article
em En
| MEDLINE
| ID: mdl-30216480
ABSTRACT
A 150-day post-metamorphosis (dpm) partial lifecycle study exposing Silurana tropicalis to <0.03 (control), 0.06, 0.13 0.25, 0.5 and 1.0 mg/L perfluorooctanesulfonate (PFOS) was conducted. A subset of specimens from the control and each treatment were evaluated at metamorphic completion. A significant increase in the median metamorphosis time was observed in the 1.0 mg/L PFOS treatment relative to the control. A modest increase in the occurrence, but not severity, of mild follicular hypertrophy was found in thyroid glands from organisms exposed to the 0.62 and 1.1 mg/L PFOS treatments. At 150 dpm, a concentration-dependent increase in whole body PFOS residues was measured ranging from 29.6 to 163.5 mg/kg in the 0.05 and 1.1 mg/L PFOS treatments. Decreased body weight and snout-vent length were noted in specimens exposed to 1.1 mg PFOS/L at the completion of metamorphosis. Body weight was reduced in the 1.1 mg/L PFOS concentration; however, snout-vent length was not affected by PFOS exposure at 150 dpm. An increased proportion of phenotypic males were noted in the 0.62 and 1.1 mg/L PFOS treatments. Abnormal ovary development characterized by size asymmetry, necrosis and formation of excessive fibrous connective tissue was identified in females exposed to 0.29 and 1.1 mg PFOS/L. Asymmetrically misshaped testes were found at 1.1 mg/L PFOS. Results suggested that PFOS is capable of interfering with S. tropicalis growth before metamorphic completion and growth and gonad development during juvenile development.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ovário
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Testículo
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Glândula Tireoide
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Ácidos Alcanossulfônicos
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Fluorocarbonos
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Larva
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Metamorfose Biológica
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article