Two distinct conformations of factor H regulate discrete complement-binding functions in the fluid phase and at cell surfaces.

Osborne, Amy J; Nan, Ruodan; Miller, Ami; Bhatt, Jayesh S; Gor, Jayesh; Perkins, Stephen J

Osborne, Amy J; Nan, Ruodan; Miller, Ami; Bhatt, Jayesh S; Gor, Jayesh; Perkins, Stephen J.

Afiliação

Osborne AJ; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Nan R; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Miller A; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Bhatt JS; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Gor J; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom.
Perkins SJ; From the Department of Structural and Molecular Biology, Darwin Building, University College London, Gower Street, London WC1E 6BT, United Kingdom s.perkins@ucl.ac.uk.

J Biol Chem ; 293(44): 17166-17187, 2018 11 02.

Article em En | MEDLINE | ID: mdl-30217822

Assuntos

Complemento C3b; Fator H do Complemento; Fragmentos de Peptídeos; Complemento C3b/química; Complemento C3b/genética; Complemento C3b/metabolismo; Fator H do Complemento/química; Fator H do Complemento/genética; Fator H do Complemento/metabolismo; Cristalografia por Raios X; Humanos; Fragmentos de Peptídeos/química; Fragmentos de Peptídeos/genética; Fragmentos de Peptídeos/metabolismo; Ligação Proteica; Conformação Proteica; Domínios Proteicos; Ressonância de Plasmônio de Superfície; Difração de Raios X

Palavras-chave

C3b activity; Monte Carlo modeling; X-ray scattering; analytical ultracentrifugation; complement; complement regulation; immune system; innate immunity; molecular modeling; solution structure; surface plasmon resonance (SPR)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Complemento C3b / Fator H do Complemento Tipo de estudo: Clinical_trials / Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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