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Functional Proteomics and Deep Network Interrogation Reveal a Complex Mechanism of Action of Midostaurin in Lung Cancer Cells.
Ctortecka, Claudia; Palve, Vinayak; Kuenzi, Brent M; Fang, Bin; Sumi, Natalia J; Izumi, Victoria; Novakova, Silvia; Kinose, Fumi; Remsing Rix, Lily L; Haura, Eric B; Koomen, John Matthew; Rix, Uwe.
Afiliação
  • Ctortecka C; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Palve V; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Kuenzi BM; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612; Cancer Biology PhD Program, University of South Florida, Tampa, Florida 33620.
  • Fang B; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Sumi NJ; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612; Cancer Biology PhD Program, University of South Florida, Tampa, Florida 33620.
  • Izumi V; Proteomics and Metabolomics Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Novakova S; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Kinose F; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Remsing Rix LL; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Haura EB; Department of Thoracic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Koomen JM; Department of Molecular Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612.
  • Rix U; Department of Drug Discovery, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612. Electronic address: uwe.rix@moffitt.org.
Mol Cell Proteomics ; 17(12): 2434-2447, 2018 12.
Article em En | MEDLINE | ID: mdl-30217950
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Carcinoma Pulmonar de Células não Pequenas / Proteínas de Ciclo Celular / Estaurosporina / Proteômica / Aurora Quinase A / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Tirosina Quinases / Proteínas Proto-Oncogênicas / Proteínas Serina-Treonina Quinases / Carcinoma Pulmonar de Células não Pequenas / Proteínas de Ciclo Celular / Estaurosporina / Proteômica / Aurora Quinase A / Neoplasias Pulmonares Tipo de estudo: Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article