Your browser doesn't support javascript.
loading
Can Population Modelling Principles be Used to Identify Key PBPK Parameters for Paediatric Clearance Predictions? An Innovative Application of Optimal Design Theory.
Calvier, Elisa A M; Nguyen, Thu Thuy; Johnson, Trevor N; Rostami-Hodjegan, Amin; Tibboel, Dick; Krekels, Elke H J; Knibbe, Catherijne A J.
Afiliação
  • Calvier EAM; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Gorlaeus Laboratories, Leiden University, Einstein weg 55, 2333 CC, Leiden, The Netherlands.
  • Nguyen TT; IAME, UMR 1137, INSERM, University Paris Diderot, Sorbonne Paris Cité, Paris, France.
  • Johnson TN; Simcyp Limited, Sheffield, UK.
  • Rostami-Hodjegan A; Simcyp Limited, Sheffield, UK.
  • Tibboel D; Manchester Pharmacy School, University of Manchester, Manchester, UK.
  • Krekels EHJ; Intensive Care and Department of Pediatric Surgery, Erasmus University Medical Center - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Knibbe CAJ; Division of Systems Biomedicine and Pharmacology, Leiden Academic Centre for Drug Research (LACDR), Gorlaeus Laboratories, Leiden University, Einstein weg 55, 2333 CC, Leiden, The Netherlands.
Pharm Res ; 35(11): 209, 2018 Sep 14.
Article em En | MEDLINE | ID: mdl-30218393
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Taxa de Depuração Metabólica / Descoberta de Drogas / Fígado / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Simulação por Computador / Taxa de Depuração Metabólica / Descoberta de Drogas / Fígado / Modelos Biológicos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article