An indole diterpenoid isolated from the fungus Drechmeria sp. and its antimicrobial activity.
Nat Prod Res
; 33(19): 2770-2776, 2019 Oct.
Article
em En
| MEDLINE
| ID: mdl-30221546
ABSTRACT
One new indole diterpenoid, drechmerin I (1), was isolated from the fermentation broth of Drechmeria sp. isolated from the root of Panax notoginseng. Its structure was elucidated based on 1 D and 2 D nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectrum (HRESIMS), and electronic circular dichroism (ECD) spectroscopic analyses as well as TD DFT calculations of ECD spectra. Drechmerin I (1) was assayed for its antimicrobial activity against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin I (1) showed antimicrobial activities against B. subtillis with an MIC value of 200 µg/mL. The interaction of S. aureus peptide deformylase with drechmerin I (1) was investigated by molecular docking.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alcaloides Indólicos
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Alcaloides Diterpenos
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Hypocreales
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Anti-Infecciosos
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article