HLA-A, -B, -DRB1, -DQA1, and -DQB1 profile in a population from southern Brazil.

ABSTRACT

The aim of this study was to determine the allele and haplotype frequencies of HLA-A, -B, -DRB1, and -DQB1 in a self-declared White population from the north and northwestern state of Paraná, southern Brazil, and compare the data with populations worldwide. The genotyping was performed with a group of 641 individuals, based on PCR-SSO and -SSP methods, and allele and haplotype frequencies were estimated. Comparisons with European, African, Asian, and Amerindian populations were performed. The most frequent allelic groups, alleles and haplotypes were HLA-A*02, HLA-B*35, HLA-DRB1*0701, HLA-DQB1*0301, and HLA-A*01/B*08/DRB1*0301. The results reinforced a predominance of a European composition in the self-declared White population from the north and northwestern Paraná.