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RK-287107, a potent and specific tankyrase inhibitor, blocks colorectal cancer cell growth in a preclinical model.
Mizutani, Anna; Yashiroda, Yoko; Muramatsu, Yukiko; Yoshida, Haruka; Chikada, Tsubasa; Tsumura, Takeshi; Okue, Masayuki; Shirai, Fumiyuki; Fukami, Takehiro; Yoshida, Minoru; Seimiya, Hiroyuki.
Afiliação
  • Mizutani A; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Yashiroda Y; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Muramatsu Y; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Yoshida H; Division of Molecular Biotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan.
  • Chikada T; Pharmacokinetics and Analysis Laboratory, Meiji Seika Pharma Co., Ltd, Kohoku-ku, Yokohama, Japan.
  • Tsumura T; Medicinal Chemistry Laboratory, Pharmaceutical Research Center, Meiji Seika Pharma Co., Ltd, Kohoku-ku, Yokohama, Japan.
  • Okue M; Process Chemistry Laboratory Chemistry, Manufacturing & Control Research Labs, Meiji Seika Pharma Co., Ltd, Kohoku-ku, Yokohama, Japan.
  • Shirai F; Drug Discovery Chemistry Platform Unit, RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Fukami T; RIKEN Program for Drug Discovery and Medical Technology Platforms, Wako, Japan.
  • Yoshida M; Chemical Genomics Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan.
  • Seimiya H; Drug Discovery Seed Compounds Exploratory Unit, RIKEN Center for Sustainable Resource Science, Wako, Japan.
Cancer Sci ; 109(12): 4003-4014, 2018 Dec.
Article em En | MEDLINE | ID: mdl-30238564
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína da Polipose Adenomatosa do Colo / Tanquirases / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Proteína da Polipose Adenomatosa do Colo / Tanquirases / Inibidores Enzimáticos / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article