Impact of Sex on the Outcome of Isolated Aortic Valve Replacement and the Role of Different Preoperative Profiles.
J Cardiothorac Vasc Anesth
; 33(5): 1237-1243, 2019 May.
Article
em En
| MEDLINE
| ID: mdl-30245111
ABSTRACT
OBJECTIVE:
The aim of this study was to compare the patient profiles and outcomes of men and women undergoing isolated aortic valve replacement.DESIGN:
Patient data were analyzed retrospectively.SETTING:
This single-center study was performed at Catharina Hospital in Eindhoven, the Netherlands.PARTICIPANTS:
The study comprised 2,362 patients, of whom 1,040 (44%) were women and 1,322 were men (56%).INTERVENTIONS:
Isolated aortic valve replacement was performed between January 1998 and December 2016. MEASUREMENTS AND MAINRESULTS:
The mean follow-up was 8.3 ± 5.1 years. Women were relatively older (69.9 years v 64.6 years; p < 0.001); more of them were underweight, obese, and diabetic; and they had lower hemoglobin values and worse renal function than did men. However, fewer women than men experienced chronic obstructive pulmonary disease, aortic regurgitation, left ventricular dysfunction, and endocarditis. Early mortality did not differ significantly between men and women (pâ¯=â¯0.238). Overall survival was worse in women (p < 0.001). After correction for potential risk factors, female sex was not associated with worse survival. During the study period, the mean age of patients undergoing aortic valve replacement increased. In addition, the mean age at the time of death increased, following the trend of national statistics.CONCLUSIONS:
Although women undergoing aortic valve replacement have relatively more risk factors than do men, early mortality in women is not significantly higher than in men. Overall survival is worse in women than in men; however, after adjustment for preoperative risk factors, there is no difference in overall survival between women and men.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estenose da Valva Aórtica
/
Cuidados Pré-Operatórios
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Caracteres Sexuais
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Implante de Prótese de Valva Cardíaca
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article