Sex-hormone-driven innate antibodies protect females and infants against EPEC infection.
Nat Immunol
; 19(10): 1100-1111, 2018 10.
Article
em En
| MEDLINE
| ID: mdl-30250184
ABSTRACT
Females have an overall advantage over males in resisting Gram-negative bacteremias, thus hinting at sexual dimorphism of immunity during infections. Here, through intravital microscopy, we observed a sex-biased difference in the capture of blood-borne bacteria by liver macrophages, a process that is critical for the clearance of systemic infections. Complement opsonization was indispensable for the capture of enteropathogenic Escherichia coli (EPEC) in male mice; however, a faster complement component 3-independent process involving abundant preexisting antibodies to EPEC was detected in female mice. These antibodies were elicited predominantly in female mice at puberty in response to estrogen regardless of microbiota-colonization conditions. Estrogen-driven antibodies were maternally transferrable to offspring and conferred protection during infancy. These antibodies were conserved in humans and recognized specialized oligosaccharides integrated into the bacterial lipopolysaccharide and capsule. Thus, an estrogen-driven, innate antibody-mediated immunological strategy conferred protection to females and their offspring.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caracteres Sexuais
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Infecções por Escherichia coli
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Imunidade Inata
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Anticorpos Antibacterianos
Limite:
Animals
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Female
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Humans
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Infant
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Male
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Pregnancy
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article