The influence of lifestyle, diet, and reproductive history on age at natural menopause in Spain: Analysis from the EPIC-Spain sub-cohort.
Am J Hum Biol
; 30(6): e23181, 2018 11.
Article
em En
| MEDLINE
| ID: mdl-30251288
ABSTRACT
OBJECTIVE:
To determinate the role of lifestyle factors, recent diet, menstrual factors, and reproductive history in age at natural menopause in adult Spanish women.METHODS:
In total, 12 562 pre-menopausal women were available for analysis from the EPIC-Spain sub-cohort. Women were recruited between 1992 and 1996 in five regions of Spain (Asturias, Granada, Murcia, Navarra, and San Sebastian) and, for these analyses, were followed for 3 years. Questionnaires on diet, lifestyle, anthropometric measurements, and reproductive and exogenous hormones history were collected at baseline. Menopause status was updated at a median of 3 years of follow-up.RESULTS:
After a median of 3 years of follow-up 1166 women became postmenopausal. An earlier age at menopause was observed in current smokers (HR 1.29; 95%CI 1.08-1.55) and in non-users of oral contraceptives (HR 1.32; 95%CI 1.01-1.57). A later age at menopause was observed in women with irregular menses (HR 0.71; 95%CI 0.56-0.91) and in women with a higher number of pregnancies (HR 0.74; 95%CI 0.56-0.94).CONCLUSIONS:
Our results confirm that women who smoked had an earlier age at natural menopause, while use of oral contraceptives, higher number of pregnancies, and irregularity of menses were associated with a prolonged reproductive lifespan. No associations were observed for dietary habits assessed after the age of 40 years.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Menopausa
/
História Reprodutiva
/
Dieta
/
Estilo de Vida
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
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Female
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Humans
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Middle aged
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article